The Faculty Room is located on the first floor in the west wing of Akademi High School.
In early builds, the Faculty Room was called the "Faculty Office" and was located on the first floor of Akademi High School, as the second and last room on the left. It was completely empty, and had grey floors and white walls. In the May 24th, 2015 Build, this room had a bookshelf, a table with chairs, a couple of boxes, a photocopier, and a potted plant on a desk. The design was for that build only and was removed in a later build.
There are six desks arranged in a single block in the middle of the room. Each desk is cluttered with books and stationary supplies. On the walls around the room, there is a speaker, a wall clock and a bulletin board. Other furniture include some bookshelves, chairs, tables, boxes, garbage cans, a printer and a coffee machine.
Teachers and other faculty members will stay here during lunchtime, before and after school. During classtime, the room is monitored by the gym teacher. There is an answer sheet on the desk that Yandere-chan can use to expel a rival. If she steals the answer sheet, she can give it to Info-chan to duplicate. Stealing the sheet produces a sound that will attract nearby NPCs, if Yandere-chan is seen by a faculty member while stealing the sheet, she will receive a game over. After the paper has been copied, she must place a sheet back onto the table to not get caught, while the extra answer sheet goes in the rival's desk. If the answer sheet is not placed back inside the faculty room, a teacher will notice the paper is missing and change all the answers, forfeiting the opportunity to expel the rival. When class is not in session, students with the Teacher's Pet personality will run directly to the faculty room in order to report something.
In the future, the faculty room will play a role in several different aspects of the game. 
- Teachers will pick up dangerous objects and bring them to the faculty room, so if the player drops a weapon with their fingerprints on it, they will have to steal it from the faculty room in order to dispose of the evidence.
- Extremely important items (like keys that will allow the player to access the tranquilizer, poison, or acid) will be located in the faculty room, guarded by teachers during most of the day.
- Any screams heard within earshot of the faculty room will cause the teachers to go investigate, so causing trouble near the faculty room will be especially dangerous.
- The room was renovated and renamed in the November 15th, 2015 Build, but wasn't fully furnished until the March 16th, 2016 Build. More furniture was added in the June 29th, 2016 Build.
- There used to be an Easter Egg in the form of a book written by Senpai called How to Hentai without Hentai-ing. It was located on the bookshelf. YandereDev has declared this non-canon.
- The desk that Shiori Risa sits at has three notes, one of them says "Speak to Senpai" another says "Bake a Cake for Senpai".
- The desk that Rino Fuka sits at has a to-do list with two separate notes. On the yellow note it says, "Advise staff about suspicious individuals sighted near school zone" On the purple note it says, "Inform students of suspicious individuals sighted nearby".
- In the bookshelves, there are several books called "How to Murder for Love."
- Similarly to the Student Council room and Art room, Yandere-chan can clip through most of the bookshelves and lockers in this room.