This room is located on the first floor in the western wing. As of the July 19th, 2017 Build the room has a pink and white scheme. It is slightly cluttered. A couple of lights and an air conditioner hang from the ceiling. There are three cots with white curtains between them on the western side of the room. In the middle of the room, there is a table with four chairs surrounding it.
In the northern corner of the room is an eye chart, a scale, and a height measure. The syringe is located on a desk next to them. There is also a tall glass cabinet on the eastern side.
On the southern side lays a large couch and cork board with a hand washing sign.
The room used to have a white floor with light grey walls, but the office was eventually renovated to a brighter color scheme, complete with a beige hardwood floor.
This is supposed to be the room where the nurses will work. The syringe and tranquilizer are both located in this room for kidnapping. The tranquilizer is located on a desk to the right of Nasu. Nasu will patrol the infirmary, with keys to the cabinet hanging off her back pocket.
Yandere-chan can attempt to steal the keys to the cabinet when Nasu isn't looking, which will trigger a series of quick-time events. If Yandere-chan fails any of the quick-time events, if Nasu turns around, or another student enters the room, Yandere-chan will be caught stealing and be expelled, resulting in a game over. If Yandere-chan successfully steals Nasu's keys, she can unlock the cabinet and take the poison inside.
if Yandere-chan is injured by the delinquents, she will be able to rest in the infirmary to heal, however, she will miss class time and as a result, will lose reputation.
In the future, Yandere-chan will have to find a way to take the tranquilizer and the syringe without Nasu noticing, such as Yandere-chan poisoning another student's food non-lethally to distract the future nurses. While Nasu is distracted, Yandere-chan will be able to steal the equipment. Yandere-chan can also attempt to take the tranquilizer and syringe when Nasu's back is turned and there is no one else in the room. The tranquilizer and syringe are necessary for kidnapping students.
- The room was renovated in the November 15th, 2015 Build.
- This room used to be a store bought model from the Unity Asset Store named Japanese School Infirmary Set.
- The room was renamed from "Nurse's Office" to "Infirmary" in the July 12th, 2016 Build.
- However, the HUD still says "Nurse's Office".