These characters are the most important people to Yandere Simulator's plot. Some of the main characters are not implemented yet.
- Main Article: Ayano Aishi
Ayano Aishi, also known as Yandere-chan, is the main character of "Yandere Simulator". The player's job is to eliminate all rivals before the week's current rival can confess their feeling to Senpai.
If the player does not successfully eliminate the rival before Friday, they will confess their feelings to him, and Senpai will accept them. This will cause a Game Over.
- Main Article: Senpai
Taro Yamada, more commonly referred to as Senpai, is a main character of "Yandere Simulator". He is Yandere-chan's love interest and obsession. She can confess her feelings to him after all ten rivals have been eliminated. However, it won't be accepted if her reputation is below -100, which will cause a Game Over.
If she fails to eliminate the week's current rival, they will confess their feelings to Senpai, who will accept them. Yandere-chan will become heartbroken and will receive a Game Over.
- Main Article: Info-chan
Info-chan is a main character in "Yandere Simulator", and is Yandere-chan's main source of assistance. Males and females alike give her money in exchange for panty shots of students.
Info-chan can give Yandere-chan all the information she has on an NPC with AI if she is sent a picture of their face. If Yandere-chan sends her panty shots, Info-chan can provide other services, such as Schemes and Drops.
Info-chan will not be in 1980's Mode.
- Main Article: Ryoba Aishi
The mother of Yandere-chan, who is also a yandere and will be the protagonist of 1980s Mode. She will not appear in Story Mode for 10 weeks, as she is hunting down The Journalist. The Basement Tapes explain more of her backstory.
- Main Article: Yandere-chan's Father
- Main Article: Rivals
Every week during the 10 weeks in the game, a new female student will fall in love with Senpai and become Yandere-chan's rival. It is Yandere-chan's goal to eliminate the rival before Friday of each current week. There will be one rival per week.
If she fails to do so, her rival will confess her love to Senpai and Yandere-chan will be left heartbroken. Hanako Yamada won't confess her love to Senpai: instead, she will make him promise to never date, so that she may have all of his attention.
Rivals have not been fully implemented yet, but when they are, the first girl planned to rival for Senpai's affections is Osana Najimi.